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  • Human Dectin-1/CLEC7A (Fc Tag) recombinant protein

Human Dectin-1/CLEC7A (Fc Tag) recombinant protein

Cat.#: 504147

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Product Information

  • Product Name
    Human Dectin-1/CLEC7A (Fc Tag) recombinant protein
  • Documents
  • Description
    Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
  • Protein name
    C-type lectin domain family 7 member A
  • Protein short names
    BETA-GLUCAN RECEPTOR; CLECSF12; CLEC7A; CANDF4; DECTIN-1; BGR; DECTIN1; BETA-GR
  • Uniprot ID
    Q9BXN2
  • Gene Name
    DKFZp686L24211; CLEC7A
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human Dectin1 (NP_072092.2) (Thr 66- Met201) was expressed with the Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human Dectin1/Fc comprises 373 amino acids and has a predicted molecular mass of 42.1 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Validations

    Human CLEC7A / Dectin-1 / CLECSF12 Protein (Fc Tag) SDS-PAGE

    Human CLEC7A / Dectin-1 / CLECSF12 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"