Anti-CLEC7A antibody

Anti-CLEC7A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Monoclonal to Mouse CLEC7A

FCM

Mouse Dectin-1 / CLEC7A

beta-glucan receptor antibody; beta-glucan receptor antibody; BGR antibody; BGR antibody; CANDF4 antibody; CLEC7A antibody; CLECSF12 antibody; Clecsf12 antibody; BGR antibody; CANDF4 antibody; DECTIN1 antibody; CLECSF12 antibody; BGR antibody; beta-GR antibody; Clecsf12 antibody; Dectin-1 antibody; Dectin-1 antibody; DECTIN1 antibody; beta-GR antibody; Clec7a antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Dectin-1 / CLEC7A (rM Dectin-1 / CLEC7A; NP_064392.2; Phe69-Leu244) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

• Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
• Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
• Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
• Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
• Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.