Human Cyclin D1 Recombinant protein (His tag)

Human Cyclin D1 Recombinant protein (His tag)

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Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {PubMed:15241418, PubMed:16569215, PubMed:18417529, PubMed:9106657}.

G1/S-specific cyclin-D1

BCL1; PRAD1

Q6FI00

CCND1; BCL1; PRAD1

E. coli

A DNA sequence encoding the human CCND1 (NP_444284.1) 65-245 aa was fused with the polyhistidine tag

Human

Not tested.