Human CRIP2 (His & GST Tag) recombinant protein

Cat.#: 503499

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Product Information

  • Product Name
    Human CRIP2 (His & GST Tag) recombinant protein
  • Documents
  • Description
    CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-?B/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.
  • Protein name
    Cysteine-rich protein 2
  • Protein short names
    AW743261; 0610010I23RIK; LIM DOMAIN PROTEIN ESP1/CRP2; CRP2; ESP1; CRP4; LIM ONLY PROTEIN HLP; CYSTEINE-RICH INTESTINAL PROTEIN; C77570; HLP; CRIP2; CYSTEINE-RICH PROTEIN 2; CRIP; CRP; CRP-2; HEART LIM PROTEIN; CYSTEINE RICH PROTEIN 2
  • Uniprot ID
    P52943
  • Gene Name
    CRIP2; CRP2
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CRIP2 (P52943) (Met1-Pro208) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CRIP2/GST chimera consists of 445 amino acids and has a calculated molecular mass of 50.3 kDa. The recombinant protein migrates as an approximately 49 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human CRIP2 Protein (His & GST Tag) SDS-PAGE

    Human CRIP2 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"