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Product Name
Human CRIP2 recombinant protein
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Description
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-?B/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.
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Protein name
Cysteine-rich protein 2
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Protein short names
AW743261; 0610010I23RIK; LIM DOMAIN PROTEIN ESP1/CRP2; CRP2; ESP1; CRP4; LIM ONLY PROTEIN HLP; CYSTEINE-RICH INTESTINAL PROTEIN; C77570; HLP; CRIP2; CYSTEINE-RICH PROTEIN 2; CRIP; CRP; CRP-2; HEART LIM PROTEIN; CYSTEINE RICH PROTEIN 2
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Uniprot ID
P52943
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Gene Name
CRIP2; CRP2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CRIP2 (P52943) (Met1-Pro208) was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human CRIP2 consists of 210 amino acids and predicts a molecular mass of 22.6 KDa. It migrates as an approximately 26 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human CRIP2 Protein SDS-PAGE
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