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Product Name
Human Complement component 7 (His Tag) recombinant protein
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Description
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
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Protein name
Complement component C7
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Protein short names
GM1238; A530026G17; COMPLEMENT COMPONENT C7
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Uniprot ID
P10643
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Gene Name
C7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human C7 (P10643) (Met1-Gln843) with a C-terminal polyhistidine tag was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human C7 comprises 832 amino acids and has a predicted molecular mass of 92.6 kDa. The apparent molecular mass of the protein is approximately 92-98 kDa in SDS-PAGE under reducing conditions.
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Purity
> 88 % as determined by SDS-PAGE
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Validations
Human C7 / Complement component 7 Protein (His Tag) SDS-PAGE
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