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Product Name
Human CD81 / TAPA-1 (Fc Tag) recombinant protein
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Description
CD81, also known as TAPA-1, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via the B cell receptor by bridging Ag specific recognition and CD21-mediated complement recognition.
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Protein name
Tetraspanin
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Protein short names
CD81 ANTIGEN; S5.7; TAPA-1; CVID6; TETRASPANIN-28; CD81; 26 KDA CELL SURFACE PROTEIN TAPA-1; TSPAN28; CD81 ANTIGEN (TARGET OF ANTIPROLIFERATIVE ANTIBODY 1); CD81 MOLECULE; TAPA1; TSPAN-28; TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1
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Uniprot ID
P60033
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Gene Name
CD81; hCG_15478
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD81 (NP_004347.1) (Phe113-Lys201) was expressed with the Fc region of mouse IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD81/mFc comprises 325 amino acids and has a predicted molecular mass of 36.4 kDa. The apparent molecular mass of the monomer is approximately 38-42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
(94.0 %+4.4) % as determined by SDS-PAGE
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Validations
Human CD81 / TAPA-1 Protein (Fc Tag) SDS-PAGE
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