Human CALCOCO2 Recombinant protein (GST tag)

Human CALCOCO2 Recombinant protein (GST tag)

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Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {PubMed:17635994, PubMed:22246324, PubMed:23022382, PubMed:23386746, PubMed:25771791}.

Calcium-binding and coiled-coil domain-containing protein 2

NDP52

Q13137

CALCOCO2; NDP52

E. coli

A DNA sequence encoding the human CALCOCO2 (NP_005822.1) 1-283 aa was fused with the N-terminal GST tag

Human

Not tested.