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Product Name
Human BUB1B Recombinant protein (GST tag)
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Description
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {PubMed:10477750, PubMed:11702782, PubMed:14706340, PubMed:15020684, PubMed:19411850, PubMed:19503101}.
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Protein name
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
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Protein short names
BUBR1; MAD3L; SSK1
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Uniprot ID
O60566
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Gene Name
BUB1B; BUBR1; MAD3L; SSK1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human BUB1B (NP_001202.5) 719-1050 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human BUB1B SDS-PAGE
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