Human BMP-2 recombinant protein
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
Bone morphogenetic protein 2
Protein short names
BDA2; AI467020A; BMP2; BMP2A; RP23-384M14.3; AI467020; BDA2A
A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln283-Arg396) was expressed. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa.
> 95 % as determined by SDS-PAGE
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 μg/ml.
Human BMP-2 / BMP2A Protein SDS-PAGE
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