Human BMP-2 (Fc Tag) recombinant protein
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
Bone morphogenetic protein 2
Protein short names
RP23-384M14.3; AI467020; BDA2A ; BDA2; BMP2A; AI467020A; BMP2
A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the C-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
The recombinant human BMP2 consists of 351 amino acids and has a predicted molecular mass of 39.5 kDa.
> 95 % as determined by SDS-PAGE and SEC-HPLC Analysis.
1.Measured by its ability to bind recombinant human Nog-Fc (Cat:503229) in a functional ELISA.
2. Measured by its ability to bind recombinant human ALK3-Fch (Cat:500360) in a functional ELISA.
3. Measured by its ability to bind recombinant mouse ALK3-Fch (Cat:504114) in a functional ELISA.
4. Measured by its ability to bind recombinant human BMPR-II-Fc (Cat:502741) in a functional ELISA.
Human BMP-2 Protein (Fc Tag) SDS-PAGE
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