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Product Name
Human BCL2L1/BCL2L/BCLX (His tag) recombinant protein
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Description
Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
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Protein name
BCL2 like 1(BCL2L1)
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Protein short names
BCL2L; BCLX
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Uniprot ID
Q07817
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human BCL2L1/BCL2L/BCLX Met1-Arg212 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human BCL2L1/BCL2L/BCLX (His tag) recombinant protein
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