Human BCL2L11 / Bim (His Tag) recombinant protein

Human BCL2L11 / Bim (His Tag) recombinant protein

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• Material Safety Data Sheets (MSDS)

B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1) , belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apoptosis independent of additional signals. The crystal and solution structures of a Bcl-2 family member, Bcl-xL is like this: The structures consist of two central, primarily hydrophobic α-helices, which are surrounded by amphipathic helices. A 60-residue loop connecting helices αl and α2 was found to be flexible and non-essential for anti-apoptotic activity. Bcl-xL is chareacterized as important factors in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca²⁺ to regulate both autophagy and apoptosis. Bcl-xL is also implicated in anoxia induced cell death. The pathway is initiated by the loss of function of the prosurvival Bcl-2 family members Mcl-1 and Bcl-2 / Bcl-XL, resulting in Bax- or Bak-dependent release of cytochrome c and subsequent caspase-9-dependent cell death. Thus, Bcl-xL, the well-characterized apoptosis guards, appears to be important in cell death.

Bcl-2-like protein 1

PPP1R52; RP23-106A3.4; BCL-X; BCL2-L-1; RP5-857M17.3; BCL(X)L; BCL-XS; BCLX; BCL-XL/S; BCLXL; MGC113803; BCL-XL; BCL2L; BCLXS; DKFZP78

Q07817

BCL2L1; BCL2L; BCLX

E. coli

A DNA sequence encoding the human BCL2L11 (NP_612815.1) (Ala2-Arg120) was expressed with a polyhistide tag at the N-terminus.

Human

The recombinant human BCL2L11 consists of 130 amino acids and predicts a molecular mass of 15 KDa. It migrates as an approximately 16-20 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE