Human AXIN1 Recombinant protein (GST tag)

Human AXIN1 Recombinant protein (GST tag)

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Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {PubMed:12192039, PubMed:16601693, PubMed:17210684}.

Axin-1

AXIN

O15169

AXIN1; AXIN

E. coli

A DNA sequence encoding the human AXIN1 (XP_011520984.1) 50-400 aa was fused with the N-terminal GST tag

Human

Not tested.