AXIN1 antibody

AXIN1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

AXIN1 Rabbit Polyclonal antibody. Positive WB detected in HT-1080 cells, A431 cells, A549 cells. Observed molecular weight by Western-blot: 100-110kd

ELISA, WB

Human; other species not tested.

AXIN antibody; axin 1 antibody; AXIN1 antibody; Axis inhibition protein 1 antibody; hAxin antibody

Rabbit IgG

This antibody was obtained by immunization of AXIN1 recombinant protein (Accession Number: NM_181050). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Axis inhibition protein1 (AXIN1), also called AXIN, together with AXIN2 are multidoman scaffold proteins that negatively regulate Wnt signaling. AXIN1 is likely to function as a tumor suppressor. Under UV irradiation, AXIN1-HIPK2-TP53 complex forms. The complex also controls cell growth, apoptosis and development. Like AXIN2, AXIN1 undergoes poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2 followed by unbiquitination by RNF146 which leads to its degradation and subsequent activation of Wnt signaling. Its deubiquitination by USP34 is important for nuclear accumulation during Wnt signaling. Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibdy raised against the N-terminus of human AXIN1.

• Zha L, Zhang J, Tang W. HMGA2 elicits EMT by activating the Wnt/β-catenin pathway in gastric cancer. Digestive diseases and sciences. 58(3):724-33. 2013.