Human APTX Recombinant protein (His tag)

Human APTX Recombinant protein (His tag)

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DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. {PubMed:14755728, PubMed:15044383, PubMed:16547001, PubMed:16964241, PubMed:17276982}.

Aprataxin

AXA1

A0A0A0MRW7

APTX; AXA1

E. coli

A DNA sequence encoding the human APTX (NP_001182178.1) 1-164 aa was fused with the polyhistidine tag

Human

Not tested.