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Product Name
Human APEX1/APE/APE1/APEX/APX/HAP1/REF1 recombinant protein
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Description
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
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Protein name
apurinic/apyrimidinic endodeoxyribonuclease 1(APEX1)
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Protein short names
APE; APE1; APEX; APX; HAP1; REF1
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Uniprot ID
P27695
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human APEX1/APE/APE1/APEX/APX/HAP1/REF1 Pro2-Leu318 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human APEX1/APE/APE1/APEX/APX/HAP1/REF1 recombinant protein
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