Human ACVR2B (Fc & His tag) recombinant protein

Human ACVR2B (Fc & His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.

activin A receptor type 2B(ACVR2B)

Q13705

Human Cells

A DNA sequence encoding the Human ACVR2B Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.