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Product Name
HTR3A antibody
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Description
HTR3A Rabbit Polyclonal antibody. Positive WB detected in mouse lung tissue, human brain tissue. Positive IHC detected in human small intestine tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
5 HT 3 antibody; 5 HT3 A antibody; 5 HT3A antibody; 5 HT3R antibody; 5 hydroxytryptamine receptor 3 antibody; 5HT3R antibody; HTR3 antibody; HTR3A antibody; Serotonin receptor 3A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HTR3A recombinant protein (Accession Number: NM_000869). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:111711(HTR3A antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:111711(HTR3A Antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:111711(HTR3A Antibody) at dilution of 1:50 (under 10x lens)
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Background
HTR3A (5-hydroxytryptamine receptor 3A, 5-HT3A) belongs to the ligand-gated ion channel receptor superfamily. It is the subunit A of the type 3 receptor for 5-hydroxytryptamine (5-HT, serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. So far, five distinct 5-HT3 receptor subunits (A-E) have been identified. HTR3A can form functional homomers or heteromers with HTR3B or HTR3C or HTR3D or HTR3E. 5-HT3 receptors are capable of mediating fast excitatory neurotransmission in the CNS and peripheral nervous system (PNS). (PMID: 23038271; 17073663)
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References
- Loyd DR, Sun XX, Locke EE, Salas MM, Hargreaves KM. Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp. Pain. 153(10):2061-7. 2012.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"