HPSE antibody

HPSE antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HPSE Rabbit Polyclonal antibody. Positive IF detected in HeLa cells, HepG2 cells. Positive IHC detected in human liver cancer tissue, human placenta tissue. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 60 kDa

ELISA, WB, IHC, IF

Human, Mouse; other species not tested.

Endo glucoronidase antibody; HEP antibody; heparanase antibody; Heparanase 1 antibody; HPA antibody; Hpa1 antibody; HPR1 antibody; HPSE antibody; HPSE1 antibody; HSE1 antibody

Rabbit IgG

This antibody was obtained by immunization of HPSE recombinant protein (Accession Number: NM_001098540). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

HPSE(Heparanase) is also named as HEP, HPA, HPA1, HPR1, HPSE1, HSE1 and belongs to the glycosyl hydrolase 79 family. It is a endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. HPSE is essential in the disassembly of the extracellular matrix (ECM) by invading cells. It has 3 isoforms produced by alternative splicing with the molecular weight of 61 kDa, 55 kDa and 53 kDa. The full length protein has six glycosylation sites. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation and glycosylation of the 50 kDa subunit appears to be essential for its solubility.

• Wang X, Zuo D, Chen Y. Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer. British journal of cancer. 111(10):1965-76. 2014.