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HLX antibody

Cat.#: 111435

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Product Information

  • Product Name
    HLX antibody
  • Documents
  • Description
    HLX Rabbit Polyclonal antibody. Positive IHC detected in human endometrial cancer tissue. Positive WB detected in human placenta tissue. Observed molecular weight by Western-blot: 50 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    H2.0 like homeobox antibody; H2.0 like homeobox protein antibody; HB24 antibody; HLX antibody; HLX1 antibody; Homeobox protein HB24 antibody; Homeobox protein HLX1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of HLX recombinant protein (Accession Number: NM_021958). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:111435(HLX antibody) at dilution of 1:500

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:111435(HLX antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:111435(HLX antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:111435(HLX antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:111435(HLX antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:111435(HLX antibody) at dilution of 1:100 (under 40x lens)

  • Background
    In immune system, Hlx is a Th1-special transcription factor that interacts specifically with T-bet, and synergistically they promote IFN-γ expression when co-expressed. It can down-regulate the IL-4 receptor expression in naive CD4+ T cells [PMID:14688316]. Over expression of Hlx contributes ot the aberrant expression of IFN-γ in normal CD4+ T cells during the differentiation under Th2-polarizing conditions. In addition, Hlx is a negative regulator of IFN-γ production in NK cells and its inhibitory function is achieved at least in part through the proteasomal degradation of STAT4 [PMID:16424184].
  • References
    • Liu T, Chen J, Xiao S, Lei X. H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"