HER2/ErbB2 antibody

HER2/ErbB2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HER2/ErbB2 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, MCF7 cells. Positive IHC detected in human breast cancer tissue, Breast Cancer slides. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 185 kDa

ELISA, WB, IF, IHC

Human; other species not tested.

CD340 antibody; ERBB2 antibody; HER 2 antibody; HER 2/neu antibody; HER2 antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NGL antibody; p185 antibody; p185erbB2 antibody; Proto oncogene c ErbB 2 antibody; Proto oncogene Neu antibody; TKR1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_004448). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.