Haptoglobin antibody

Haptoglobin antibody

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Haptoglobin Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, human liver tissue. Positive IP detected in HepG2 cells. Positive IHC detected in human liver tissue, mouse liver tissue. Observed molecular weight by Western-blot: 42 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

HAPT antibody; Haptoglobin antibody; HP2 ALPHA 2 antibody; HPA1S antibody

Rabbit IgG

This antibody was obtained by immunization of Haptoglobin recombinant protein (Accession Number: BC058031). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

HP(Haptoglobin) is also named as zonulin and belongs to the peptidase S1 family. HP, a plasma glycoprotein that binds free hemoglobin, has a tetrameric structure of 2 alpha(16 kDa and 9 kDa) and 2 beta(40 kDa) polypeptides that are covalently associated by disulfide bonds. In most species, apart from ruminants, Hp has a molecular mass of 100 kDa, consisting of two subunits of 40 kDa and two subunits of 9 kDa, although in a few species, such as man, genetic variant of Hp forms polymers of higher mass(PMID:2361363). Recent studies of haptoglobin show that certain oligosaccharide structures predominate in different diseases. For example, a highly-fucosylated structure is found in breast cancer and ovarian cancer, highly-sialylated structures in Crohn’s disease and highly branched structures in alcoholic liver disease and fucosylated haptoglobin is a good serum marker for pancreatic cancer.(PMID:16385567).

• Tan Y, Ma SY, Wang FQ. Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer. Oncology reports. 26(4):853-9. 2011.
• Shen H, Heuzey E, Mori DN. Haptoglobin enhances cardiac transplant rejection. Circulation research. 116(10):1670-9. 2015.