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Product Name
Human GOLM1/GP73 (His Tag) recombinant protein
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Description
Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2 and GOLM1, is a protein which belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in colon, prostate, trachea and stomach. It is expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression of GOLM1 does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), GOLM1 is strongly expressed in hepatocyte-derived syncitial giant cells. GOLM1 is constitutively expressed by biliary epithelial cells but not by hepatocytes.
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Protein name
Golgi membrane protein 1
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Protein short names
AW125446; FLJ23608; RP11-379P1.3; FLJ22634; C9ORF155; GOLM1; D030064E01RIK; PSEC0257; GP73; MGC107447; BA379P1.3; HEL46; GOLPH2; 2310001L02RIK
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Uniprot ID
Q8NBJ4
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Gene Name
GOLM1; C9orf155; GOLPH2; PSEC0242; UNQ686/PRO1326
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human GOLM1 isoform 1 (Q8NBJ4-1) (Met 1-Leu 401) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GOLM1 consisting of 417 amino acids and has a calculated molecular mass of 47.4 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human GOLM1 / GP73 Protein (His Tag) SDS-PAGE
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