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Product Name
GLRX3 antibody
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Description
GLRX3 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue, human ovary tumor tissue. Positive IF detected in Hela cells. Positive WB detected in human brain tissue, Jurkat cells. Observed molecular weight by Western-blot: 37kd
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
bA500G10.4 antibody; FLJ11864 antibody; GLRX3 antibody; GLRX4 antibody; Glutaredoxin 3 antibody; GRX3 antibody; GRX4 antibody; PICOT antibody; PKC theta interacting protein antibody; PKCq interacting protein antibody; Thioredoxin like protein 2 antibody; TXNL2 antibody; TXNL3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GLRX3 recombinant protein (Accession Number: BC014372). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111036(GLRX3 antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:111036(GLRX3 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:111036(GLRX3 antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of Hela cells, using GLRX3 antibody Catalog No:111036 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
GLRX3(Glutaredoxin-3) is also named as PICOT, TXNL2. Mammalian glutaredoxin 3 is an essential protein involved in the regulation of signal transduction, for instance during immune cell activation and development of cardiac hypertrophy, presumably in response to redox signals(PMID:20226171). Glrx3 could take a pivotal role in colon and lung cancer cells during the tumorigenesis, which is expressed in lung and colon cancers consistently and preferentially(PMID:19797004).
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References
- Lee EJ, In KH, Kim JH. Proteomic analysis in lung tissue of smokers and COPD patients. Chest. 135(2):344-52. 2009.
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