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GLRX2 antibody

Cat.#: 111035

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Product Information

  • Product Name
    GLRX2 antibody
  • Documents
  • Description
    GLRX2 Rabbit Polyclonal antibody. Positive IF detected in A549 cells. Positive WB detected in A549 cells, human heart tissue, mouse heart tissue. Observed molecular weight by Western-blot: 16 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    bA101E13.1 antibody; GLRX2 antibody; Glutaredoxin 2 antibody; Glutaredoxin 2 antibody; mitOChondrial antibody; GRX2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of GLRX2 recombinant protein (Accession Number: NM_001243399). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IF: 1:50-1:500

  • Validations

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111035(GLRX2 antibody) at dilution of 1:200

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111035(GLRX2 antibody) at dilution of 1:200

    Immunofluorescent analysis of (10% Formaldehyde) fixed A549 cells using Catalog No:111035(GLRX2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (10% Formaldehyde) fixed A549 cells using Catalog No:111035(GLRX2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    GLRX2(Glutaredoxin-2) is also named as GRX2 and belongs to the glutaredoxin family. It facilitates the maintenance of cellular redox homeostasis upon treatment with apoptotic agents, thereby preventing cardiolipin oxidation and cytochrome C release. The GLRX2, which exists in a dynamic equilibrium of enzymatically active monomers and quiescent dimers,is a 16-kDa protein directed either to the nucleus or to the mitochondria through differential splicing of the first exon(PMID: 17121859). It has 2 isoforms produced by alternative splicing.
  • References
    • Manabe Y, Takagi M, Nakamura-Yamada M. Redox proteins are constitutively secreted by skeletal muscle. The journal of physiological sciences : JPS. 64(6):401-9. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"