-
Product Name
GJB3 antibody
- Documents
-
Description
GJB3 Rabbit Polyclonal antibody. Positive IHC detected in human cervix tissue, human ovary tumor tissue, human skin cancer tissue. Positive WB detected in mouse ovary tissue, HeLa cells, human brain tissue, human heart tissue. Observed molecular weight by Western-blot: 31 kDa
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
Connexin 31 antibody; CX31 antibody; DFNA2 antibody; DFNA2B antibody; EKV antibody; FLJ22486 antibody; Gap junction beta 3 protein antibody; GJB3 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of GJB3 recombinant protein (Accession Number: NM_024009). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
mouse ovary tissue were subjected to SDS PAGE followed by western blot with Catalog No:110984(GJB3 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human cervix tissue slide using Catalog No:110984(GJB3 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human cervix tissue slide using Catalog No:110984(GJB3 Antibody) at dilution of 1:50 (under 40x lens)
-
Background
GJB3, also known as Connexin-31 (Cx31), belongs to the connexin family. Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. Mutations in the gene of GJB3 have been described in patients with dominant and recessive hearing impairment and in patients with erythrokeratodermia variabilis (EKV).
-
References
- Nishiyama M, Nita A, Yumimoto K, Nakayama KI. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem cells (Dayton, Ohio). 33(11):3327-40. 2015.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"