GGCX antibody

GGCX antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

GGCX Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human brain tissue. Positive WB detected in MCF7 cells, HEK-293 cells, HepG2 cells, L02 cells, mouse liver tissue, PC-3 cells. Positive IP detected in mouse liver tissue. Observed molecular weight by Western-blot: 88 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

FLJ26629 antibody; gamma glutamyl carboxylase antibody; GGCX antibody; VKCFD1 antibody

Rabbit IgG

This antibody was obtained by immunization of GGCX recombinant protein (Accession Number: NM_000821). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

GGCX(Gamma-glutamyl carboxylase) is also named as GC and belongs to the vitamin K-dependent gamma-carboxylase family. This 94 kDa (including all modifications, such as the five N-linked glycosylations), is a 5-pass transmembrane protein and a key regulator of blood coagulation(PMID:20518534). It mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1) and pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD)(PMID:9845520;17110937).

• Ferron M, Lacombe J, Germain A, Oury F, Karsenty G. GGCX and VKORC1 inhibit osteocalcin endocrine functions. The Journal of cell biology. 208(6):761-76. 2015.