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  • GFI1 antibody

GFI1 antibody

Cat.#: 110946

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Special Price 239.0 USD

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Product Information

  • Product Name
    GFI1 antibody
  • Documents
  • Description
    GFI1 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HL-60 cells, PC-3 cells, Raji cells, RAW264.7 cells. Observed molecular weight by Western-blot: 62-66 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FLJ94509 antibody; GFI 1 antibody; GFI1 antibody; Zinc finger protein 163 antibody; Zinc finger protein Gfi 1 antibody; ZNF163 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of GFI1 recombinant protein (Accession Number: BC032751). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110946(GFI1 antibody) at dilution of 1:500

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110946(GFI1 antibody) at dilution of 1:500

  • Background
    GFI is a transcriptional repressor that is transiently induced during T-cell differentiation. It has critical roles in enhancing T helper-2 (Th2) cell expansion and in repressing induction of Th17 and CD103-positive inducible regulatory T (Treg) cells [PMID: 19188499]. The growth factor independent 1 (GFI1) transcriptional regulator oncoprotein plays a crucial role in hematopoietic, inner ear, and pulmonary neuroendocrine cell development and governs cell processes as diverse as self-renewal of hematopoietic stem cells, proliferation, apoptosis, differentiation, cell fate specification, and oncogenesis [PMID: 18805794]. The calculated molecular weight of GFI1 protein is about 45 kDa, but the modification of ubiquitinated GIF1 protein is about 62-66 kDa [PMID: 12721361].
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"