GCNF antibody

GCNF antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

GCNF Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue. Positive IP detected in mouse testis tissue. Positive WB detected in PC-3 cells, K-562 cells, mouse testis tissue. Observed molecular weight by Western-blot: 55 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

GCNF antibody; GCNF1 antibody; Germ cell nuclear factor antibody; hGCNF antibody; hRTR antibody; NR61 antibody; NR6A1 antibody; RTR antibody

Rabbit IgG

This antibody was obtained by immunization of GCNF recombinant protein (Accession Number: NM_001489). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

NR6A1 (Nuclear Receptor Subfamily 6 Group A member), also known as GCNF (Germ Cell Nuclear Factor), is an orphan member of the nuclear receptor gene superfamily. It has been shown to be expressed in the nervous system during development and during specific stages in maturing germ cells of the ovary and testis in the adult, and has probable roles in gametogenesis, neurogenesis, and normal embryonic development during gastrulation. Inactivation of GCNF in mouse results in abnormal posterior development, impaired midbrain development, insufficient closure of the neural tube, and eventual embryonic death. GCNF has been shown to be a repressor of ocT-4 and of the protamine genes and plays a critical role in the control of gene expression during embryogenesis and spermatogenesis. This antibody specifically reacts with the 55kd NR6A1 protein.