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Product Name
Rat GGT1 (His Tag) recombinant protein
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Description
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism (By similarity).
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Protein name
Gamma-glutamyltranspeptidase 1
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Protein short names
GGT; DWG; GAMMA-GLUTAMYLTRANSPEPTIDASE 1; GGT 1; GGTP; GTG; LEUKOTRIENE-C4 HYDROLASE; D22S672; GGT1; GLUTATHIONE HYDROLASE 1; CD224; GAMMA-GLUTAMYL TRANSPEPTIDASE; GGT-1; D22S732; GLUTAMYL TRANSPEPTIDASE
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Uniprot ID
P07314
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Gene Name
Ggt1; Ggt
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat GGT1 (P07314) (Pro27-Tyr568) was expressed, fused with a polyhistidine tag at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat GGT1 comprises 562 amino acids and has a predicted molecular mass of 61.1 kDa. The apparent molecular mass of the protein is approximately 54-57 kDa in SDS-PAGE under reducing conditions.
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Purity
> 70 % as determined by SDS-PAGE
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Validations
Rat GGT1 Protein (His Tag) SDS-PAGE
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