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Product Name
FKBP8 Polyclonal Antibody
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Description
Polyclonal antibody to FKBP8
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Tested applications
WB, IF, IP
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Species reactivity
Human, Mouse
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Alternative names
FKBP8 antibody; FKBP38 antibody; FKBPr38 antibody; FK506 binding protein 8 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human FKBP8
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IF 1:20 - 1:100
IP 1:20 - 1:50 -
Validations
Western blot - FKBP8 Polyclonal Antibody
Western blot analysis of extracts of Jurkat cells, using FKBP8 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"