Human FGFR4/CD334 (Fc Tag) recombinant protein

Cat.#: 501464

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human FGFR4/CD334 (Fc Tag) recombinant protein
  • Documents
  • Description
    Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
  • Protein name
    Fibroblast growth factor receptor 4
  • Protein short names
    TKF; JTK2; FGFR-4; CD334; FGFR4; MGC20292
  • Uniprot ID
    P22455
  • Gene Name
    FGFR4; JTK2; TKF
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Asp 369) of human FGFR4 (NP_002002.3) precursor was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FGFR4/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 586 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh FGFR4/Fc monomer is approximately 100-110 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit FGF-acidic (aFGF / FGF1) dependent proliferation of BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 2-6 ng/ml.
  • Validations

    Human FGFR4 / FGF Receptor 4 Protein (Fc Tag) SDS-PAGE

    Human FGFR4 / FGF Receptor 4 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"