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FERMT3 antibody

Cat.#: 110621

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Special Price 239.0 USD

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Product Information

  • Product Name
    FERMT3 antibody
  • Documents
  • Description
    FERMT3 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, Raji cells. Positive IF detected in HeLa cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 72-76kd
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Fermitin family homolog 3 antibody; FERMT3 antibody; KIND3 antibody; Kindlin 3 antibody; MIG 2 antibody; MIG2 like protein antibody; MIG2B antibody; Unc 112 related protein 2 antibody; UNC112C antibody; URP2 antibody; URP2SF antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FERMT3 recombinant protein (Accession Number: NM_001382361). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:110621(FERMT3 antibody) at dilution of 1:300

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:110621(FERMT3 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:110621(FERMT3 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:110621(FERMT3 antibody) at dilution of 1:50 (under 10x lens)

    Immunofluorescent analysis of HeLa cells using Catalog No:110621(FERMT3 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HeLa cells using Catalog No:110621(FERMT3 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    Kindlin-3 (FERMT-3) is known to be central in hemostasis and thrombosis control and its deficiency disrupts platelet aggregation and causes Leukocyte Adhesion Deficiency disease. Point mutations in the kindlin-3 gene have been identified in humans with a rare inherited Integrin Activation eficiency Disease (IADD), also designated as Leukocyte Adhesion Deficiency syndrome (LAD-III or LADI variant). Kindlin-3 expression is restricted to cells of hematopoietic origin. This antibody works well in WB, IHC and IF applications.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"