FCRL3 Polyclonal Antibody
Polyclonal antibody to FCRL3
Human, Mouse, Rat
FCRL3 antibody; CD307c antibody; FCRH3 antibody; IFGP3 antibody; IRTA3 antibody; SPAP2 antibody; Fc receptor like 3 antibody
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human FCRL3 (NP_443171.2).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
IHC 1:100 - 1:200
Western blot - FCRL3 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using FCRL3 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 30s.
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells.
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