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Product Name
FANCD2 Polyclonal Antibody
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Description
Polyclonal antibody to FANCD2
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Tested applications
WB
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Species reactivity
Human
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Alternative names
FANCD2 antibody; FA-D2 antibody; FA4 antibody; FACD antibody; FAD antibody; FAD2 antibody; FANCD antibody; Fanconi anemia group D2 protein antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human FANCD2
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
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Validations
Western blot - FANCD2 Polyclonal Antibody
Western blot analysis of extracts of Jurkat cells, using FANCD2 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"