EXOSC2 antibody

EXOSC2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

EXOSC2 Mouse Monoclonal antibody. Positive WB detected in Jurkat cells, HEK-293 cells, HeLa cells, HepG2 cells. Positive IF detected in HepG2 cells. Positive IHC detected in human liver tissue, human skin cancer tissue. Observed molecular weight by Western-blot: 33kD

ELISA, WB, IF, IHC

Human; other species not tested.

EXOSC2 antibody; exosome component 2 antibody; hRrp4p antibody; RRP4 antibody; Rrp4p antibody

Mouse IgG2a

This antibody was obtained by immunization of EXOSC2 recombinant protein (Accession Number: NM_014285). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563].