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Product Name
Human EIF5A (His Tag) recombinant protein
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Description
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
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Protein name
Eukaryotic translation initiation factor 5A-1
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Protein short names
D19WSU54E; AA410058; EIF5AI; EIF5A1; EIF5A; EIF4D1; EIF-5A; RP23-172M21.7; EIF-5A-1; EIF4D; EIF-5A1; EIF-4D
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Uniprot ID
P63241
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Gene Name
EIF5A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human EIF5A (NP_001961.1) (Met1-Lys154) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human EIF5A consists of 170 amino acids and predicts a molecular mass of 18.9 kDa. It migrates as an approximately 21 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human EIF5A Protein (His Tag) SDS-PAGE
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