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Product Name
ERBB4 antibody
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Description
ERBB4 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 147 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
4ICD antibody; E4ICD antibody; ERBB4 antibody; HER4 antibody; p180erbB4 antibody; s80HER4 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001042599). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110403(ERBB4 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110403(ERBB4 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110403(ERBB4 antibody) at dilution of 1:100 (under 40x lens)
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Background
ERBB4, also named as p180erbB4 and HER4, belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. ERBB4 specifically binds and it is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. ERBB4 is not activated by EGF, TGF-A, and amphiregulin. ERBB4 catalyze the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. The antibody recognize the C-term of ERBB4.
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