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Product Name
ERBB3 antibody
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Description
ERBB3 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 185kd
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
c erbB 3 antibody; c erbB3 antibody; ErbB 3 antibody; ERBB3 antibody; erbB3 S antibody; HER3 antibody; LCCS2 antibody; MDA BF 1 antibody; p180 ErbB3 antibody; p45 sErbB3 antibody; p85 sErbB3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ERBB3 recombinant protein (Accession Number: BC002706). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110402(ERBB3 antibody) at dilution of 1:10 (under 40x lens)
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:110402(ERBB3 Antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:110402(ERBB3 Antibody) at dilution of 1:200 (under 40x lens)
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Background
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB-3, HER3) is a member of the EGF receptor tyrosine kinase family including EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4) that are frequently overexpressed in a variety of carcinomas. These family members form either homodimers or heterodimers upon ligand binding to mediate cell growth. ErbB-3 binds and is activated by neuregulins and NTAK. It forms a heterodimer with each of the other ErbB receptors. ErbB-3 is predominantly expressed in epithelial tissues and brain, and is overexpressed in a subset of human mammary tumors.
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