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Product Name
Endothelin 1 antibody
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Description
Endothelin 1 Rabbit Polyclonal antibody. Positive WB detected in human ileum tissue, SGC-7901 cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 24 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
EDN1 antibody; endothelin 1 antibody; ET 1 Big endothelin 1 antibody; ET1 antibody; HDLCQ7 antibody; PPET1 antibody; Preproendothelin 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Endothelin 1 recombinant protein (Accession Number: NM_001955). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human ileum tissue were subjected to SDS PAGE followed by western blot with Catalog No:110250(EDN1 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:110250(EDN1 antibody) at dilution of 1:50 (under 25x lens)
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Background
EDN1, also named as Endothelin-1, PPET1 and ET-1, belongs to the endothelin/sarafotoxin family. Endothelins are endothelium-derived vasoconstrictor peptides. Emerging basic science, and animal and human data all suggest that EDN1 is a potentially important contributor in the pathobiology of fibrosing disorders, including those that affect the lung(PMID:20055532 ).
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References
- Ha NH, Nair VS, Reddy DN. Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Cancer research. 71(23):7259-69. 2011.
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