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Product Name
Endostatin antibody
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Description
Endostatin Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in human liver tissue, human kidney tissue. Observed molecular weight by Western-blot: 19 kDa,27 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
COL18A1 antibody; Collagen alpha 1(XVIII) chain antibody; collagen antibody; type XVIII antibody; alpha 1 antibody; Endostatin antibody; FLJ27325 antibody; FLJ34914 antibody; KNO antibody; KNO1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_130445). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:110249(Endostatin, COL18A1 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human liver using Catalog No:110249(Endostatin, COL18A1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:110249(Endostatin, COL18A1 antibody) at dilution of 1:50 (under 40x lens)
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Background
Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from COL18A1 (also named as KNO). It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It potently inhibits endothelial cell proliferation and inhibits endothelial cell angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
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