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Product Name
Human Autotaxin/ENPP2 (His Tag) recombinant protein
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Description
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
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Protein name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
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Protein short names
FLJ26803; AUTOTAXIN; NPP2; NPPS2; ATX-X; ATX; ENPP2; PDNP2; PD-IALPHA; LYSOPLD
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Uniprot ID
Q13822
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Gene Name
ENPP2; ATX; PDNP2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human ENPP2 (AAH34961.1) (Asp 49-Ile 863) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ENPP2 consists of 834 amino acids and has a calculated molecular mass of 96 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhENPP2 is approximately 120-130 kDa due to glycosylation.
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Purity
> 88 % as determined by SDS-PAGE
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Validations
Human Autotaxin / ENPP2 / NPP2 Protein (His Tag) SDS-PAGE
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