ENPP2 Polyclonal Antibody

Cat.#: 162978

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Product Information

  • Product Name
    ENPP2 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to ENPP2
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    ENPP2 antibody; ATX antibody; ATX-X antibody; AUTOTAXIN antibody; LysoPLD antibody; NPP2 antibody; PD-IALPHA antibody; PDNP2 antibody; ectonucleotide pyrophosphatase/phosphodiesterase 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 564-863 of human ENPP2 (NP_001035181.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - ENPP2 Polyclonal Antibody

    Western blot - ENPP2 Polyclonal Antibody

    Western blot analysis of extracts of human brain, using ENPP2 antibody at dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"