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Product Name
DVL2 Polyclonal Antibody
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Description
Polyclonal antibody to DVL2
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Tested applications
IHC, IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
DVL2 antibody; dishevelled segment polarity protein 2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IHC 1:50 - 1:200
IF 1:50 - 1:200 -
Validations
Immunofluorescence - DVL2 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using DVL2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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Background
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"