DR5-Specific antibody

DR5-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DR5-Specific Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, PC-3 cells. Observed molecular weight by Western-blot: 58-60 kDa, 45-50 kDa, 32 kDa

ELISA, WB

Human; other species not tested.

CD262 antibody; Death receptor 5 antibody; DR5 antibody; KILLER antibody; KILLER/DR5 antibody; TNFRSF10B antibody; TRAIL R2 antibody; TRAIL receptor 2 antibody; TRAILR2 antibody; TRICK2 antibody; TRICK2A antibody; TRICK2B antibody; TRICKB antibody; ZTNFR9 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003842). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TNFRSF10B, also known as CD262, DR5, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells (PMID: 9311998). TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which TNFRSF10B is capable to transmit the apoptotic signal (PMID: 9311998; 20531300). In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa(PMID:20354842). The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner, and these receptor dimers exist within high molecular weight networks(Dr. Jonathan N. Sachs,2012).