Product Name

DMXL2 antibody

Documents

Description

DMXL2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IHC detected in human cerebellum tissue, human kidney tissue. Observed molecular weight by Western-blot: 340 kDa

Tested applications

ELISA, WB, IHC

Species reactivity

Human, Mouse, Rat; other species not tested.

Alternative names

Dmx like 2 antibody; DmX like protein 2 antibody; DMXL2 antibody; FLJ26672 antibody; KIAA0856 antibody; Rabconnectin 3 antibody; RC3 antibody

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of DMXL2 recombinant protein (Accession Number: NM_001174117). Purification method: Antigen affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

WB: 1:200-1:1000

IHC: 1:20-1:200

Validations

mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110076(DMXL2 Antibody) at dilution of 1:200

Immunohistochemistry of paraffin-embedded human cerebellum slide using Catalog No:110076(DMXL2 Antibody) at dilution of 1:50

Background

DMXL2, also named as rabconnectin-3, is a functional regulator of mammalian notch signaling with WD domains. Rabconnectin-3 is abundantly expressed in the brain where it is enriched in the synaptic vesicle fraction. Immunofluorescence and immunoelectron microscopy revealed that rabconnectin-3 was concentrated on synaptic vesicles at synapses. It may serve as a scaffold molecule for both Rab3 GEP and GAP on synaptic vesicles. In western blotting, we got 340 kDa and 104 kDa in mouse tissues. The two bands may represent different isoforms.

References

Faronato M, Nguyen VT, Patten DK. DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation. Oncotarget. 6(26):22467-79. 2015.

DMXL2 antibody

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