Mouse ADAM15 (His Tag) recombinant protein

Mouse ADAM15 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.

Disintegrin and metalloproteinase domain-containing protein 15

MDC15; METARGIDIN; ADAM15; RP11-540D14.1

O88839

Adam15; Mdc15

Human Cells

A DNA sequence encoding the mouse ADAM15 (O88839-1) extracellular domain (Met 1-Thr 697) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse ADAM15 (pro form) comprises 691 amino acids and has a calculated molecular mass of 74.6 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 80-90 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE

1. Measured by its ability to bind human PTK6 in a functional ELISA.
2. Measured by its ability to bind human SRC in a functional ELISA.
3. Measured by its ability to bind mouse SRC in a functional ELISA.
4. Measured by its ability to bind human LYN in a functional ELISA.