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Product Name
Human ADAM15 (His Tag) recombinant protein
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Description
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
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Protein name
Disintegrin and metalloproteinase domain-containing protein 15
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Protein short names
MDC15; METARGIDIN; ADAM15; RP11-540D14.1
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Uniprot ID
Q13444
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Gene Name
ADAM15; MDC15
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ADAM15 (Q13444-1) (Met 1-Thr 696) precursor was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human ADAM15 (mature form) comprises 501 amino acids after proteolytic of the signal peptide and pro peptide and has a predicted molecular mass of 54 kDa. As a result of glycosylation, rhADAM15 migrates as an approximately 65-70 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human ADAM15 Protein (His Tag) SDS-PAGE
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