Mouse DPP4 / CD26 (His Tag) recombinant protein

Mouse DPP4 / CD26 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Dipeptidyl peptidase 4

ADABP; DPP-4; ADCP2; THAM; DPPIV; TP103; DPP4; CD26

Q3TR43

Dpp4; Cd26

Human Cells

A DNA sequence encoding the mouse Dpp4 (NP_034204.1) (Ser29-His760) was expressed with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse Dpp4 consists 743 amino acids and predicts a molecular mass of 85.9 kDa.

> 90 % as determined by SDS-PAGE.